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Subject: [ERROR] Areas pending, text probably lost in line
I read through the archives dealing with : [ERROR] Areas pending, text probably lost in linea heterodimer to the cis-regulatory region of terminal differentiation marker genes such as the genes coding for vesicular neurotransmitter transporters But can not determine the fix to my problem, which is generated by the <para> below. When I remove the last sentence, the error vanishes. Similarly, when I simply add more characters (e.g. 2312312312312 21312323232123123123121231231211231231211 231231232 231232 23232 2312312 123123 1111111 ) to end of the sentence the error also vanishes. Could someone please suggest a fix? Thank you in advance, Tristan <caption> <formalpara> <title>Figure 3. Combinatorial gene expression patterns determine cell fates</title> <para>(A) "X" and "Y" indicate a gene regulatory factor(s) that determine pan-neuronal ("1") versus cell type specific characters ("2", "3"). Factor Y (which should be considered not necessarily as a single factor but a combination of several regulatory factors that form a specific "code") induces neuron-class specific features both directly ("2") and indirectly, via other gene regulatory factors ("3"; factors Z1, Z2, etc.). The principle of a cell-fate determinant acting both directly and indirectly on terminal differentiation markers is a widespread theme. One example is shown in panel B. Other examples include the organ selector gene <emphasis>pha-4</emphasis> (Gaudet and Mango, 2002), the <emphasis>unc-86</emphasis> gene (Finney and Ruvkun, 1990; Xue et al., 1993 ; Duggan et al., 1998) or, in other systems, the eye-selector Pax-6/eyeless (Gehring, 2002). (B,C) Examples and elaborations of the concept shown in panel A. (B) Differentiation of the AIY interneuron class. TTX-3 and CEH-10 proteins bind directly as a heterodimer to the cis-regulatory region of terminal differentiation marker genes such as the genes coding for vesicular neurotransmitter transporters (<emphasis>unc-17</emphasis>), neurotransmitter receptors (<emphasis>gar-2</emphasis> and others) and scores of other genes identified by genome wide searches (Wenick and Hobert, 2004). TTX-3 and CEH-10 also activate intermediate factors such as CEH-23, which are required for the expression of specific subfeature of the neuron (Altun-Gultekin et al., 2001). The "?" indicates that the <emphasis>wrk-1</emphasis> gene is expressed in a <emphasis>ttx-3/ceh-10</emphasis> dependent manner, but contains no <emphasis>ttx-3/ceh-10</emphasis> binding motif, hence invoking an intermediate transcription factor. (C) Differentiation of the ASE neuron class, composed of ASEL and ASER. Both cells are bilaterally symmetric in terms of morphology and the expression of many terminal differentiation markers (such as <emphasis>flp-6</emphasis> or <emphasis>hen-1</emphasis>, as well as many others), yet express distinct chemoreceptors, encoded by the <emphasis>gcy</emphasis> genes. A bistable loop composed of transcription factors and miRNAs (Johnston et al. submitted) drives differentiation into the ASEL state (<emphasis>gcy-7</emphasis> expression) or the ASEP state (<emphasis>gcy-5</emphasis> expression). </para> </formalpara> </caption>
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